David Sharp, Co-Founder & CSO
"Wound healing can be made into a fast recovery process with a lower risk of infection, high fidelity resulting in the reduction in endured pain, decreased scarring, as well as shorter hospital stays.” This above statement might be mind-boggling for many individuals as recovery from such wounds usually involves a prolonged healing process that is too often accompanied by disfiguring scars. But not for David J. Sharp, a professor at Albert Einstein College of Medicine in New York and the co-founder and Chief Science Officer of MicroCures—a biotech startup that is developing a siRNA technology for wound healing and focuses on unlocking the natural healing power of living cells.
While researching the regulation of microtubules in cells in his lab, he found that some poorly characterized genes can actively control cellular motility by regulating the microtubule side of the cell’s internal skeleton. “We are finding ways to unlock cells’ natural abilities to induce regeneration. Microtubules are a key element in controlling cell motility, and we have found that profound changes can be induced by selectively turning off the expression of certain genes within a reasonable period, making cells optimally regenerative,” explains Sharp. To address the challenges of accelerated healing and tissue repair in acute wounds and the current therapeutic standards in the regenerative medicine landscape, he founded MicroCures along with an experienced entrepreneur at the Silicon Valley—Derek Proudian, the Co-Founder and CEO of MicroCures.
MicroCures has developed non-invasive methods with no apparent side effects for using microtubules in controlling and directing cell motion to appropriately respond to various injuries and accelerate the natural healing process quickly.
Derek Proudian, Co-Founder & CEO
MicroCures’ patented technology targets specific Microtubule Regulatory Proteins (MRPs)—for their healing effect on cell behavior. With a unique approach of targeting a specific and very defined mechanism, which temporarily, topically, and reliably harnesses the internal mechanics of particular cells so that they rapidly move into and work productively within a specified wound, MicroCures has developed proprietary “enhancers” and “inhibitors” of cell migration. MicroCures’ enhancer technology effectively promotes the regeneration of skin and deep tissue wounds, improves cardiac output after infarction, and can stimulate functional recovery after spinal cord and peripheral nerve injury, while the inhibitor technology effectively inhibits cancer metastasis and fibrosis.
We are finding ways to unlock cells natural abilities to induce regeneration
MicroCures unlocks the healing behaviors of the body’s cells effectively without artificially altering the signaling environment within the wound, needed for effective healing and long-term health. The tested applications of MicroCures’ platform technology include enhanced wound/burn regeneration, enhanced and localized vessel formation after cardiac infarction, neural regeneration after spinal cord injury, and inhibition of tumor metastasis. With their technology platform, MicroCures is focused on the treatment of spinal cord injury, myocardial infarction, and wound healing. “We are not manipulating signaling pathways but simply and mechanically changing the way, and the rate at which cells move. We have found ways to put our siRNA into the standardly used wound salves that can change them from being protective or antimicrobial into being regenerative,” asserts Sharp.
Steering ahead, MicroCures is developing novel nanoparticle-based therapeutics to enhance tissue regeneration and repair for improving patient outcomes. MicroCures has had positive results during their preclinical studies for peripheral nerve generation and on the regeneration of the cavernous nerve, which usually gets damaged during radical prostatectomy. As the MicroCures technology has varied applications, the company looks forward to working with theU.S. military while also identifying furtherinnovative methodologies to develop more specific applications.